The β-Carboline Analog Mana-Hox Causes Mitotic Aberration by Interacting with DNA
نویسندگان
چکیده
منابع مشابه
DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development
During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis. Here, we show that precancerous DNA lesions induced by oncogene acceleration, which induce situations identical to the initial stages of cancer development, trigger tetraploid...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2005
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2005.09.014